Coumarins are naturally occurring molecules with a versatile range of activities. Their
structural and physicochemical characteristics make them a privileged scaffold in medicinal …

Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …

The tyrosinase enzyme, which is widely found in microorganisms, animals and plants, has a
significant position in melanogenesis, plays an important role in undesirable browning of …

Skin hyperpigmentation resulting from excessive tyrosinase expression has long been a
problem for beauty lovers, which has not yet been completely solved. Although researchers …

Kojic acid has gained its importance after it was known worldwide that the substance
functions primarily as skin-lightening agent. Kojic acid plays a vital role in skin care products …

A novel series of thirty coumarin derivatives (4a∼ r, 5a∼ l) constituted by coumarin and
cinnamic acid/benzoic acid through oxime linkage were synthesized and evaluated for their …

Tyrosinase is a copper-containing enzyme which is widely distributed in nature (eg, bacteria,
mammals, fungi) and involved in two consecutive steps of melanin biosynthesis. In humans …

Tyrosinase (TYR, EC 1.14. 18.1), a critical enzyme participating in melanogenesis, catalyzes
the first two steps in melanin biosynthesis including the ortho-hydroxylation of L-tyrosine and …

The argan tree (Argania spinosa (L.) Skeels) is one of the most important floristic resources
in Morocco. This Moroccan endemic tree is known for its numerous therapeutic and …

Excessive melanin deposition may lead to a series of skin disorders. The production of
melanin is carried out by melanocytes, in which the enzyme tyrosinase performs a key role …