This chapter provides an overview of the early developmental origins of six ocular tissues:
the cornea, lens, ciliary body, iris, neural retina, and retina pigment epithelium. Many of …

The trabecular meshwork is a tissue located in the anterior chamber angle of the eye, and it
is a crucial determinant of intraocular pressure values because of its resistance to the …

BACKGROUND: Little is known about the molecular mechanisms responsible for the
development of glaucoma, the leading cause of irreversible blindness worldwide. Some …

Purpose.: Human aqueous humor (hAH) provides nutrition and immunity within the anterior
chamber of the eye. Characterization of the protein composition of hAH will identify …

Anterior segment developmental disorders, including Axenfeld–Rieger anomaly (ARA),
variably associate with harmfully elevated intraocular pressure (IOP), which causes …

Glaucoma refers to a heterogeneous group of disorders that involve retinal ganglion cell
death, optic nerve damage, and loss of visual field. Glaucoma is a leading cause of vision …

This review traces the evolution of the concept of the blood–aqueous barrier (BAB) during
the past 20 years. The Classical model simply stipulated that the tight junctions of the iris …

purpose. To characterize the gene expression pattern in the human trabecular meshwork
(TM) and identify candidate genes for glaucoma by expressed sequence tag (EST) analysis …

Over a decade has passed since myocilin was identified as the first gene linked to early and
late-onset primary open-angle glaucoma. During this time, considerable effort has been put …

The discovery in the human ocular ciliary body of glaucoma-associated genes (ie, MYOC,
CYP1B1), neuroendocrine processing enzymes, neuroendocrine peptides, steroid …