Eukaryotic cilia are organelles that project from the surface of cells to fulfill motility and
sensory functions. In vertebrates, the functions of both motile and immotile cilia are critical for …

The cilium evolved to provide the ancestral eukaryote with the ability to move and sense its
environment. Acquiring these functions required the compartmentalization of a dynein …

Cilia are evolutionarily conserved structures with many sensory and motility-related
functions. The ciliary base, composed of the basal body and the transition zone, is critical for …

Centrioles play a key role in the development of the fly. They are needed for the correct
formation of centrosomes, the organelles at the poles of the spindle that can persist as …

Ciliopathies are life‐threatening human diseases caused by defective cilia. They can often
be traced back to mutations of genes encoding transition zone (TZ) proteins demonstrating …

Centrioles are highly structured organelles whose size is remarkably consistent within any
given cell type. New centrioles are born when Polo-like kinase 4 (Plk4) recruits Ana2/STIL …

Abstract Background The Androctonus crassicauda, belonging to the genus Androctonus of
the family Buthidae, is the most venomous scorpion in Middle East countries. However, the …

Cilia are cellular projections that assemble on centriole-derived basal bodies. While cilia
assembly is absolutely dependent on centrioles, it is not known to what extent they …

Better methods are required to interpret the pathogenicity of disease-associated variants of
uncertain significance (VUS), which cannot be actioned clinically. In this study, we explore …

Polo kinase (PLK1 in mammals) is a master cell cycle regulator that is recruited to various
subcellular structures, often by its polo-box domain (PBD), which binds to phosphorylated S …