Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter
perception and mood and affect numerous cognitive processes. They are generally …

Serotonin [5-hydroxytryptamine (5-HT)] plays an important role in many organs as a
peripheral hormone. Most of the body's serotonin is circulating in the bloodstream …

Background Depression and anxiety are prevalent psychiatric disorders that carry significant
morbidity. Pharmacological and psychosocial interventions are used to manage these …

This paper introduces a new construct, the 'pivotal mental state', which is defined as a hyper-
plastic state aiding rapid and deep learning that can mediate psychological transformation …

The intestinal epithelium forms a barrier between the microbiota and the rest of the body. In
addition, beyond acting as a physical barrier, the function of intestinal epithelial cells (IEC s) …

Scientific interest in serotonergic psychedelics (eg, psilocybin and LSD; 5‐HT2A receptor
agonists) has dramatically increased within the last decade. Clinical studies administering …

Background: In the past few years, the issue of 'microdosing'psychedelics has been openly
discussed in the public arena where claims have been made about their positive effect on …

Therapeutic deficiencies with monoaminergic antidepressants invites the need to identify
and develop novel rapid-acting antidepressants. Hitherto, ketamine and esketamine are …

Abstract Serotonin (5-hydroxytryptamine, 5-HT) 2A receptor agonists have recently emerged
as promising new treatment options for a variety of disorders. The recent success of these …