The evolution of genome mining in microbes–a review
Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …
part in the discovery of novel natural products as drug leads. Thousands of bacterial …
[HTML][HTML] The secondary metabolite bioinformatics portal: computational tools to facilitate synthetic biology of secondary metabolite production
Natural products are among the most important sources of lead molecules for drug
discovery. With the development of affordable whole-genome sequencing technologies and …
discovery. With the development of affordable whole-genome sequencing technologies and …
SANDPUMA: ensemble predictions of nonribosomal peptide chemistry reveal biosynthetic diversity across Actinobacteria
MG Chevrette, F Aicheler, O Kohlbacher… - …, 2017 - academic.oup.com
Nonribosomally synthesized peptides (NRPs) are natural products with widespread
applications in medicine and biotechnology. Many algorithms have been developed to …
applications in medicine and biotechnology. Many algorithms have been developed to …
Structural basis of the nonribosomal codes for nonproteinogenic amino acid selective adenylation enzymes in the biosynthesis of natural products
Nonproteinogenic amino acids are the unique building blocks of nonribosomal peptides
(NRPs) and hybrid nonribosomal peptide–polyketides (NRP–PKs) and contribute to their …
(NRPs) and hybrid nonribosomal peptide–polyketides (NRP–PKs) and contribute to their …
Anabaena/Dolichospermum as the source of lethal microcystin levels responsible for a large cattle toxicosis event
Thirty-two 14-month old steers died during a period of four days (19–23 June 2017) after
drinking from Junipers Reservoir (southeastern Oregon, USA) during a cyanobacterial …
drinking from Junipers Reservoir (southeastern Oregon, USA) during a cyanobacterial …
Pathway for the biosynthesis of the pigment chrysogine by Penicillium chrysogenum
A Viggiano, O Salo, H Ali, W Szymanski… - Applied and …, 2018 - Am Soc Microbiol
Chrysogine is a yellow pigment produced by Penicillium chrysogenum and other
filamentous fungi. Although the pigment was first isolated in 1973, its biosynthetic pathway …
filamentous fungi. Although the pigment was first isolated in 1973, its biosynthetic pathway …
Non-ribosomal Peptide Synthetase Gene Clusters in the Human Pathogenic Fungus Scedosporium apiospermum
Y Le Govic, N Papon, S Le Gal, JP Bouchara… - Frontiers in …, 2019 - frontiersin.org
Scedosporium species are opportunistic fungi which preferentially affect patients with
underlying conditions such as immunosuppression or cystic fibrosis (CF). While being the …
underlying conditions such as immunosuppression or cystic fibrosis (CF). While being the …
Identification of Novel Rotihibin Analogues in Streptomyces scabies, Including Discovery of Its Biosynthetic Gene Cluster
S Planckaert, B Deflandre, AM De Vries… - Microbiology …, 2021 - Am Soc Microbiol
Streptomyces scabies is a phytopathogen associated with common scab disease. This is
mainly attributed to its ability to produce the phytotoxin thaxtomin A, the biosynthesis of …
mainly attributed to its ability to produce the phytotoxin thaxtomin A, the biosynthesis of …
Nonribosomal peptides in fungal cell factories: from genome mining to optimized heterologous production
A Vassaux, L Meunier, M Vandenbol, D Baurain… - Biotechnology …, 2019 - Elsevier
Fungi are notoriously prolific producers of secondary metabolites including nonribosomal
peptides (NRPs). The structural complexity of NRPs grants them interesting activities such …
peptides (NRPs). The structural complexity of NRPs grants them interesting activities such …
Characterization of a Citrulline 4‐Hydroxylase from Nonribosomal Peptide GE81112 Biosynthesis and Engineering of Its Substrate Specificity for the Chemoenzymatic …
The GE81112 tetrapeptides are a small family of unusual nonribosomal peptide congeners
with potent inhibitory activity against prokaryotic translation initiation. With the exception of …
with potent inhibitory activity against prokaryotic translation initiation. With the exception of …