The life history of cancer cells encompasses a series of genetic missteps in which normal
cells are progressively transformed into tumor cells that invade surrounding tissues and …

Many components of mitogenic signaling pathways in normal and neoplastic cells have
been identified, including the large family of protein kinases, which function as components …

PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4)(IC50, 0.011
μmol/L) and Cdk6 (IC50, 0.016 μmol/L), having no activity against a panel of 36 additional …

A pharmacological approach to inhibition of cyclin-dependent kinases 4 and 6 (Cdk4/6)
using highly selective small molecule inhibitors has the potential to provide novel cancer …

We have investigated the contribution of CDK4 and CDK2 inhibition to G1 arrest in colon
cancers following inhibition of the MEK/MAP kinase pathway. CDK4 inhibition is sufficient to …

The structures and biological activities of naturally occurring 3‐alkenyl‐oxindoles are
reviewed. Important man‐made3‐alkenyl‐oxindoles are covered, particularly those with …

Abstract Indirubin, a 3, 2'bisindole isomer of indigo, has originally been identified as the
active principle of a traditional Chinese preparation and has been proven to exhibit …

CDK4/6 inhibitors represent a new treatment standard for hormone receptor-positive (HR+),
HER2-negative advanced breast cancer (BC) patients. Although efficacious, resistance to …

Inhibition of the cell cycle kinase, cyclin-dependent kinase-4 (Cdk4), is expected to provide
an effective method for the treatment of proliferative diseases such as cancer. The pyrido [2 …

The cyclin D-CDK4/6 complexes play a pivotal role in controlling the cell cycle. Deregulation
in cyclin D-CDK4/6 pathway has been described in many types of cancer and it invariably …