Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

There is much interest in the use of extracellular vesicles (EVs) as a subcellular therapy for
regenerative medicine and drug delivery. Blood-borne platelets represent a source of …

Targeted drug delivery to disease-associated activated neutrophils can provide novel
therapeutic opportunities while avoiding systemic effects on immune functions. We created a …

Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …

Abstract Platelet‐rich plasma (PRP), due to its promising therapeutic properties, has been
used in regenerative medicine for more than 30 years and numerous encouraging outcomes …

Mitochondrial dysfunction causes the production of reactive oxygen species (ROS) and
oxidative damage, and oxidative stress and inflammation are considered key factors causing …

Platelets are blood cells that are primarily produced by the shedding of megakaryocytes in
the bone marrow. Platelets participate in a variety of physiological and pathological …

Venous thromboembolism (VTE) is the third leading cardiovascular cause of death and is
conventionally treated with anticoagulants that directly antagonize coagulation. However …

Platelet-derived extracellular vesicles (PEVs) are a subset of EVs that are released from
platelets, which are small nuclear cell fragments that play a critical role in hemostasis and …

Rapid hemostasis of uncontrolled bleeding following traumatic injuries, especially
accompanied by coagulopathies, remains a significant clinical challenge. Extracellular …