Neuroinflammation and COVID-19

A Vanderheiden, RS Klein - Current opinion in neurobiology, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has caused a historic pandemic of
respiratory disease. COVID-19 also causes acute and post-acute neurological symptoms …

[HTML][HTML] 'Spikeopathy': COVID-19 spike protein is pathogenic, from both virus and vaccine mRNA

PI Parry, A Lefringhausen, C Turni, CJ Neil, R Cosford… - Biomedicines, 2023 - mdpi.com
The COVID-19 pandemic caused much illness, many deaths, and profound disruption to
society. The production of 'safe and effective'vaccines was a key public health target. Sadly …

Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

C Greene, R Connolly, D Brennan, A Laffan… - Nature …, 2024 - nature.com
Vascular disruption has been implicated in coronavirus disease 2019 (COVID-19)
pathogenesis and may predispose to the neurological sequelae associated with long …

SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

FL Fontes-Dantas, GG Fernandes, EG Gutman… - Cell reports, 2023 - cell.com
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …

[HTML][HTML] Mitogen activated protein kinase (MAPK) activation, p53, and autophagy inhibition characterize the severe acute respiratory syndrome coronavirus 2 (SARS …

AM Kyriakopoulos, G Nigh, PA McCullough, S Seneff - Cureus, 2022 - ncbi.nlm.nih.gov
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and
prions use common pathogenic pathways to induce toxicity in neurons. Infectious prions …

Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers

RF Damiano, CCA Rocca, AP Serafim… - Frontiers in …, 2023 - frontiersin.org
Objective To analyze the potential impact of sociodemographic, clinical and biological
factors on the long-term cognitive outcome of patients who survived moderate and severe …

Exploring the immunogenic properties of SARS-CoV-2 structural proteins: PAMP: TLR signaling in the mediation of the neuroinflammatory and neurologic sequelae of …

MG Frank, M Fleshner, SF Maier - Brain, Behavior, and Immunity, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produces an array of
neurologic and neuropsychiatric symptoms in the acute and post-acute phase of infection …

[HTML][HTML] Clinical approach to post-acute sequelae after COVID-19 infection and vaccination

N Hulscher, BC Procter, C Wynn, PA McCullough - Cureus, 2023 - ncbi.nlm.nih.gov
The spike protein of SARS-CoV-2 has been found to exhibit pathogenic characteristics and
be a possible cause of post-acute sequelae after SARS-CoV-2 infection or COVID-19 …

SARS-CoV-2 Spike protein alters microglial purinergic signaling

VS Alves, SACS Santos, R Leite-Aguiar… - Frontiers in …, 2023 - frontiersin.org
Despite long-term sequelae of COVID-19 are emerging as a substantial public health
concern, the mechanism underlying these processes still unclear. Evidence demonstrates …

[HTML][HTML] Hippocampal alterations after SARS-CoV-2 infection: A systematic review

C Zorzo, L Solares, M Mendez… - Behavioural Brain …, 2023 - Elsevier
SARS-CoV-2 infection produces a wide range of symptoms. Some of the structural changes
caused by the virus in the nervous system are found in the medial temporal lobe, and …