Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement
therapy approach have proven to be very powerful and instrumental in biomedical research …

The discovery of induced pluripotent stem cells (iPSCs) has made an invaluable contribution
to the field of regenerative medicine, paving way for identifying the true potential of human …

Adenine base editors (ABEs) catalyze specific A-to-G conversions at genomic sites of
interest. However, ABEs also induce cytosine deamination at the target site. To reduce the …

Abstract Noonan syndrome [NS; Mendelian Inheritance in Men (MIM)# 163950] and related
syndromes [Noonan syndrome with multiple lentigines (formerly called LEOPARD …

Juvenile myelomonocytic leukemia (JMML) is a unique clonal hematopoietic disorder of
early childhood. It is classified as an overlap myeloproliferative/myelodysplastic neoplasm …

Rare hereditary disorders provide unequivocal evidence of the importance of genes in
human disease pathogenesis. Familial syndromes that predispose to osteosarcomagenesis …

Together with recent advances in the processing and culture of human tissue,
bioengineering, xenotransplantation and genome editing, Induced pluripotent stem cells …

Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a
potential immune modulator because of its role in the programmed cell death PD-L1/PD-1 …

Myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) are aggressive
myeloid malignancies recognized as a distinct category owing to their unique combination of …

The correct maintenance and differentiation of hematopoietic stem cells (HSC) in bone
marrow is vital for the maintenance and operation of the human blood system. GATA2 plays …