Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
Membrane protein structure, function, and dynamics: a perspective from experiments and theory
Membrane proteins mediate processes that are fundamental for the flourishing of biological
cells. Membrane-embedded transporters move ions and larger solutes across membranes; …
cells. Membrane-embedded transporters move ions and larger solutes across membranes; …
Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes
The structure of the protein-translocating channel SecYEβ from Pyrococcus furiosus at 3.1-Å
resolution suggests a mechanism for chaperoning transmembrane regions of a protein …
resolution suggests a mechanism for chaperoning transmembrane regions of a protein …
The bacterial Sec-translocase: structure and mechanism
JA Lycklama a Nijeholt… - … Transactions of the …, 2012 - royalsocietypublishing.org
Most bacterial secretory proteins pass across the cytoplasmic membrane via the
translocase, which consists of a protein-conducting channel SecYEG and an ATP …
translocase, which consists of a protein-conducting channel SecYEG and an ATP …
Dynamics of long-distance hydrogen-bond networks in photosystem II
F Guerra, M Siemers, C Mielack… - The Journal of Physical …, 2018 - ACS Publications
Photosystem II uses the energy of absorbed light to split water molecules, generating
molecular oxygen, electrons, and protons. The four protons generated during each reaction …
molecular oxygen, electrons, and protons. The four protons generated during each reaction …
Breaking on through to the other side: protein export through the bacterial Sec system
More than one-third of cellular proteomes traffic into and across membranes. Bacteria have
invented several sophisticated secretion systems that guide various proteins to …
invented several sophisticated secretion systems that guide various proteins to …
[HTML][HTML] Extended protein/water H-bond networks in photosynthetic water oxidation
Oxidation of water molecules in the photosystem II (PSII) protein complex proceeds at the
manganese–calcium complex, which is buried deeply in the lumenal part of PSII …
manganese–calcium complex, which is buried deeply in the lumenal part of PSII …
Arginine in membranes: the connection between molecular dynamics simulations and translocon-mediated insertion experiments
EV Schow, JA Freites, P Cheng, A Bernsel… - The Journal of …, 2011 - Springer
Several laboratories have carried out molecular dynamics (MD) simulations of arginine
interactions with lipid bilayers and found that the energetic cost of placing arginine in lipid …
interactions with lipid bilayers and found that the energetic cost of placing arginine in lipid …
Dynamic coupling of fast channel gating with slow ATP-turnover underpins protein transport through the Sec translocon
JA Crossley, WJ Allen, DW Watkins, T Sabir… - The EMBO …, 2024 - embopress.org
The Sec translocon is a highly conserved membrane assembly for polypeptide transport
across, or into, lipid bilayers. In bacteria, secretion through the core channel complex …
across, or into, lipid bilayers. In bacteria, secretion through the core channel complex …
Channel crossing: how are proteins shipped across the bacterial plasma membrane?
The structure of the first protein-conducting channel was determined more than a decade
ago. Today, we are still puzzled by the outstanding problem of protein translocation—the …
ago. Today, we are still puzzled by the outstanding problem of protein translocation—the …