Fibrinolysis is regulated by specific molecular interactions between its main components.
Activation of plasminogen by tissue-type plasminogen activator (t-PA) is enhanced in the …

Thrombin activatable fibrinolysis inhibitor (TAFI), a proenzyme, is converted to a potent
attenuator of the fibrinolytic system upon activation by thrombin, plasmin, or the thrombin …

Blood coagulation consists of a series of zymogens that can be converted by limited
proteolysis to active enzymes leading to the generation of thrombin. Fresh plasma and …

Metallocarboxpeptidases cleave C-terminal residues from peptide substrates and participate
in a wide range of physiological processes, but they also contribute to human pathology. On …

Thrombin‐activatable fibrinolysis inhibitor (TAFI) is an important regulator in the balance of
coagulation and fibrinolysis. TAFI is a metallocarboxypeptidase that circulates in plasma as …

Procarboxypeptidase U (TAFI) is a recently discovered plasma procarboxypeptidase that
upon activation by thrombin or thrombin‐thrombomodulin turns into a potent antifibrinolytic …

Roundworms of the genus Ascaris are common parasites of the human gastrointestinal tract.
A battery of selective inhibitors protects them from host enzymes and the immune system …

Carboxypeptidase A6 (CPA6) is an extracellular matrix-bound metallocarboxypeptidase
(CP) that has been implicated in Duane syndrome, a neurodevelopmental disorder in which …

In what corresponds to a life span, metallocarboxypeptidases (MCPs) have jumped from
being mere contaminants in animal pancreas powders (in depression year 1929) to be key …

Since its discovery more than 20 years ago, a lot has been revealed about the biochemistry
and physiological behaviour of carboxypeptidase U (CPU). Recent advances in CPU …