Liquid biopsies, in particular, analysis of cell-free DNA (cfDNA), have emerged as a
promising noninvasive diagnostic approach in oncology. Abnormal distribution of DNA …

DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

Cytotoxic T cells are essential mediators of protective immunity to viral infection and
malignant tumours and are a key target of immunotherapy approaches. However, prolonged …

Regulatory T cells (Treg cells), a distinct subset of CD4+ T cells, are necessary for the
maintenance of immune self-tolerance and homeostasis,. Recent studies have …

Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an
essential component of long-lived T cell immunity. These memory CD8 T cells remain …

Alveolar macrophages orchestrate the response to viral infections. Age-related changes in
these cells may underlie the differential severity of pneumonia in older patients. We …

Neuronal intranuclear inclusion disease (NIID) is a slowly progressing neurodegenerative
disease characterized by eosinophilic intranuclear inclusions in the nervous system and …

DNA methylation is prevalent in mammalian genomes and plays a central role in the
epigenetic control of development. The mammalian DNA methylation machinery is thought …

Motivation: DNA methylation is an epigenetic modification with important roles in many
biological processes and diseases. Bisulfite sequencing (BS-seq) has emerged recently as …

Organoids derived from human pluripotent stem cells recapitulate the early three-
dimensional organization of the human brain, but whether they establish the epigenomic …