A mathematical model for the role of dopamine-D2 self-regulation in the production of ultradian rhythms

AQ Zhang, MR Ralph… - PLOS Computational …, 2024 - journals.plos.org
Many self-motivated and goal-directed behaviours display highly flexible, approximately 4
hour ultradian (shorter than a day) oscillations. Despite lacking direct correspondence to …

Interplay of Cellular mRNA, miRNA and Viral miRNA during Infection of a Cell

VP Zhdanov - International Journal of Molecular Sciences, 2022 - mdpi.com
The understanding of the kinetics of gene expression in cells infected by viruses is currently
limited. As a rule, the corresponding models do not take viral microRNAs (miRNAs) into …

Mathematical insights into the role of dopamine signaling in circadian entrainment

R Kim, HF Nijhout, MC Reed - Mathematical Biosciences, 2023 - Elsevier
The circadian clock in the mammalian brain comprises interlocked molecular feedback
loops that have downstream effects on important physiological functions such as the sleep …

A mathematical model of promoter methylation in the circadian clock

TL Silverthorne - 2022 - search.proquest.com
Recent experiments suggest that DNA methylation plays a role in altering the period of the
circadian clock. We add a mechanistic perspective to these findings by showing that DNA …