Interleukin-12 is a heterodimeric cytokine produced primarily by pathogen-activated antigen-
presenting cells, particularly macrophages and dendritic cells, during encountering with …

Systemic lupus erythematosus (SLE) is a heterogeneous disease in which excessive
inflammation, autoantibodies and complement activation lead to multisystem tissue damage …

IL‐35 is a cytokine of the IL‐12 family, existing as a heterodimer of IL‐12p35 and Ebi3. IL‐35
has anti‐inflammatory properties and is produced by regulatory T cells in humans and mice …

Anti-cancer immunotherapy is encountering its own checkpoint. Responses are dramatic
and long lasting but occur in a subset of tumors and are largely dependent upon the pre …

It is known that intensive physical activity alters the immune system's functionality. However,
the influence of the intensity and duration of exercise needs to be studied in more depth. We …

Objective Type 2 conventional dendritic cells (cDC2s) are key orchestrators of inflammatory
responses, linking innate and adaptative immunity. Here we explored the regulation of …

Heat shock proteins (HSPs) were originally identified as stress-responsive proteins and
serve as molecular chaperones in different intracellular compartments. Translocation of …

Dead cells accumulating in the tissues may contribute to chronic inflammation. We
examined the cause of impaired apoptotic cell clearance in human and murine lupus. Dead …

Dendritic cells (DCs) and complement are both key members of the innate and adaptive
immune response. Recent experimental mouse models have shown that production of …

The main limitations to the success of transplantation are the antigraft response developed
by the recipient immune system, and the adverse side effects of chronic …