mRNA vaccines have recently proved to be highly effective against SARS-CoV-2. Key to
their success is the lipid-based nanoparticle (LNP), which enables efficient mRNA …

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths
worldwide. Although advances are being made towards earlier detection and the …

The ability of the adaptive immune system to form memory is key to providing protection
against secondary infections. Resident memory T cells (TRM) are specialized T cell …

Summary The Aryl hydrocarbon receptor (Ahr) regulates the differentiation and function of
CD4+ T cells; however, its cell-intrinsic role in CD8+ T cells remains elusive. Herein we …

The immunosuppressive tumor microenvironment (TME) is a formidable barrier to the
success of adoptive cell therapies for solid tumors. Oncolytic immunotherapy with …

Cancer vaccines, which activate the immune system against a target antigen, are attractive
for prostate cancer, where multiple upregulated protein targets are identified. However …

Background Programmed cell death protein-1 (PD-1) expression has been associated with
activation and exhaustion of both the CD4 and CD8 populations in advanced non-small cell …

Simple Summary Immunotherapy provides the unprecedented opportunity to prolong the
survival of cancer patients and even cure patients with previously untreatable malignancies …

Simple Summary Cytokines are molecules that help cells communicate at short range. Often,
a single cytokine is measured in patient tissues to understand whether immune cells are …

Adoptive cell therapy using TCR-engineered T cells (TCR-T cells) represents a promising
strategy for treating relapsed and metastatic cancers. We previously established methods to …