Over more than a century of research has established the fact that sleep benefits the
retention of memory. In this review we aim to comprehensively cover the field of “sleep and …

Introduction Insomnia is a stress-related sleep disorder, may favor a state of allostatic
overload impairing brain neuroplasticity, stress immune and endocrine pathways, and may …

INTRODUCTION: Extracts of the plant Passiflora incarnata L.(Passifloraceae) were
administered intraperitoneally in order to test its effects on sleep. METHOD: Experiments …

Benzodiazepines are one of the most prescribed medications as first-line treatment of
anxiety, insomnia, and epilepsy around the world. Over the past two decades, advances in …

Abstract Background Semen Ziziphi spinosae and Radix Polygalae, two herbs commonly
used together in Traditional Chinese Medicine for the treatment of insomnia and anxiety …

Homeostatic regulation of REM sleep plays a key role in neural plasticity and deficits in this
process are implicated in the development of many neuropsychiatric disorders. Little is …

Abstract Study Objectives The present study investigated the function of Hypocretin (Hcrt or
Orexin/OX) receptor antagonists in sleep modulation and memory function with optical …

Rationale Zolpidem is a positive allosteric modulator of γ-aminobutyric acid (GABA) with
preferential binding affinity and efficacy for α1-subunit containing GABA A receptors (α1 …

The hypocretin receptor (HcrtR) antagonist almorexant (ALM) has potent hypnotic actions
but little is known about neurocognitive performance in the presence of ALM. HcrtR …

Therapeutic drugs for cognitive and psychiatric disorders are often characterized by their
molecular mechanism of action. Here we demonstrate a new approach to elucidate drug …