The role of surfactant in lung disease and host defense against pulmonary infections

SH Han, RK Mallampalli - Annals of the American Thoracic Society, 2015 - atsjournals.org
Pulmonary surfactant is essential for life as it lines the alveoli to lower surface tension,
thereby preventing atelectasis during breathing. Surfactant is enriched with a relatively …

Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment

RJ Dinis-Oliveira, JA Duarte… - Critical reviews in …, 2008 - Taylor & Francis
Paraquat dichloride (methyl viologen; PQ) is an effective and widely used herbicide that has
a proven safety record when appropriately applied to eliminate weeds. However, over the …

[图书][B] Murray and Nadel's textbook of respiratory medicine E-book: 2-volume set

RJ Mason, VC Broaddus, TR Martin, TE King… - 2010 - books.google.com
Murray and Nadel's Textbook of Respiratory Medicine has long been the definitive and
comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth …

Surfactant proteins SP-A and SP-D: structure, function and receptors

U Kishore, TJ Greenhough, P Waters, AK Shrive… - Molecular …, 2006 - Elsevier
Surfactant proteins, SP-A and SP-D, are collagen-containing C-type (calcium dependent)
lectins called collectins, which contribute significantly to surfactant homeostasis and …

The American–European Consensus Conference on ARDS, part 2: ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to …

A Artigas, GR Bernard, J Carlet, D Dreyfuss… - American journal of …, 1998 - atsjournals.org
The acute respiratory distress syndrome (ARDS) continues as a contributor to the morbidity
and mortality of patients in intensive care units throughout the world, imparting tremendous …

Lung epithelium–specific proteins: characteristics and potential applications as markers

C Hermans, A Bernard - American journal of respiratory and critical …, 1999 - atsjournals.org
Conclusions The lung interfaces with the environment across a continuous and
heterogeneous epithelium. The proximal conducting airways are lined with a …

Biological markers of acute lung injury: prognostic and pathogenetic significance.

JF Pittet, RC Mackersie, TR Martin… - American journal of …, 1997 - atsjournals.org
Interest in the pathogenetic mechanisms of acute lung injury has focusd in recent years on
the cellular and biochemical mediators of the acute respiratory distress syndrome (ARDS) …

Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS

KE Greene, JR Wright, KP Steinberg… - American journal of …, 1999 - atsjournals.org
The goal of this study was to determine the changes that occur in surfactant-associated
proteins in bronchoalveolar lavage fluid (BAL) and serum of patients at risk for ARDS and …

Innate immune activation in neutrophilic asthma and bronchiectasis

JL Simpson, TV Grissell, J Douwes, RJ Scott, MJ Boyle… - Thorax, 2007 - thorax.bmj.com
Background: The role of the innate immune system in the pathogenesis of asthma is unclear.
Activation of innate immune receptors in response to bacterial lipopolysaccharide, viral …

Immunomodulatory functions of surfactant

JR Wright - Physiological reviews, 1997 - journals.physiology.org
The possibility that the lipoprotein complex of lung surfactant functions in pulmonary host
defense as well as lowering surface tension at the air-liquid interface has been the subject of …