Current and upcoming therapies to modulate skin scarring and fibrosis

JQ Coentro, E Pugliese, G Hanley, M Raghunath… - Advanced drug delivery …, 2019 - Elsevier
Skin is the largest organ of the human body. Being the interface between the body and the
outer environment, makes it susceptible to physical injury. To maintain life, nature has …

A systematic review of objective burn scar measurements

KC Lee, J Dretzke, L Grover, A Logan… - Burns & …, 2016 - academic.oup.com
Background Problematic scarring remains a challenging aspect to address in the treatment
of burns and can significantly affect the quality of life of the burn survivor. At present, there …

Keloids and hypertrophic scars: pathophysiology, classification, and treatment

B Berman, A Maderal, B Raphael - Dermatologic Surgery, 2017 - journals.lww.com
BACKGROUND Keloid and hypertrophic scars represent an aberrant response to the wound
healing process. These scars are characterized by dysregulated growth with excessive …

[HTML][HTML] A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo

J Davis, AR Burr, GF Davis, L Birnbaumer… - Developmental cell, 2012 - cell.com
After injury or cytokine stimulation, fibroblasts transdifferentiate into myofibroblasts,
contractile cells that secrete extracellular matrix for wound healing and tissue remodeling …

Keloids and hypertrophic scars: a spectrum of clinical challenges

AP Trace, CW Enos, A Mantel, VM Harvey - American journal of clinical …, 2016 - Springer
Since their earliest description, keloids and hypertrophic scars have beleaguered patients
and clinicians alike. These scars can be aesthetically disfiguring, functionally debilitating …

Topical tacrolimus for the treatment of secondary lymphedema

JC Gardenier, RP Kataru, GE Hespe… - Nature …, 2017 - nature.com
Secondary lymphedema, a life-long complication of cancer treatment, currently has no cure.
Lymphedema patients have decreased quality of life and recurrent infections with treatments …

Pharmacotherapy for keloids and hypertrophic scars

T Murakami, S Shigeki - International Journal of Molecular Sciences, 2024 - mdpi.com
Keloids (KD) and hypertrophic scars (HTS), which are quite raised and pigmented and have
increased vascularization and cellularity, are formed due to the impaired healing process of …

Pathophysiologic mechanisms and current treatments for cutaneous sequelae of burn wounds

C Hall, C Hardin, CJ Corkins, AZ Jiwani… - Comprehensive …, 2011 - Wiley Online Library
Burn injuries are a pervasive clinical problem. Extensive thermal trauma can be life‐
threatening or result in long‐lasting complications, generating a significant impact on quality …

Synthesis of poly (lactide-co-glycerol) as a biodegradable and biocompatible polymer with high loading capacity for dermal drug delivery

F Zabihi, P Graff, F Schumacher, B Kleuser, S Hedtrich… - Nanoscale, 2018 - pubs.rsc.org
Due to the low cutaneous bioavailability of tacrolimus (TAC), penetration enhancers are
used to improve its penetration into the skin. However, poor loading capacity, non …

Update on keloid management: clinical and basic science advances

MH Viera, AC Vivas, B Berman - Advances in wound care, 2012 - liebertpub.com
Background: Keloids are benign, fibroproliferative lesions that represent abnormal healing
resulting in excessive fibrosis. They are composed of mainly type III (early) or type I (late) …