Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …

Abstract The phosphatidylinositol 3-kinase (PI3K)-Akt and the mammalian target of
rapamycin (mTOR) represent two vital intracellular signaling pathways, which are …

The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell
development, as well as differentiation and survival of naive T cells, and generation and …

Metabolic rewiring and the consequent production of reactive oxygen species (ROS) are
necessary to promote tumorigenesis. At the nexus of these cellular processes is the aberrant …

Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune
system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well …

Significance: Blood forming, hematopoietic stem cells (HSCs) mostly reside in the bone
marrow in a quiescent, nonmotile state via adhesion interactions with stromal cells and …

Background Despite the high cure rate of T cell acute lymphoblastic leukemia (T-ALL), drug
resistance to chemotherapy remains a significant clinical problem. Bone marrow …

Interleukin-7 receptor α (encoded by IL7R) is essential for lymphoid development. Whether
acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger …

Abstract Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a
complex array of critical cellular processes. It was initially identified in rat skeletal muscle as …

Reactive oxygen species (ROS) are thought to have effects on T-cell function and
proliferation. Low concentrations of ROS in T cells are a prerequisite for cell survival, and …