Alzheimer's disease (AD) and Parkinson's disease (PD) are two typical neurodegenerative
diseases that increased with aging. With the emergence of aging population, the health …

Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …

Ovarian cancer is the most lethal gynecologic malignancy in the United States, with an
estimated 22,530 new cases and 13,980 deaths in 2019. Recent studies have indicated that …

Parkinson's disease is a common progressive and multifactorial neurodegenerative disease,
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …

The purpose of this study was to elucidate the mechanisms associated with the specific
effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the …

Background Cancer, as one of the main causes of human deaths, is currently a significant
global health challenge. Since the majority of cancer-related deaths are associated with late …

Ovarian cancer is the most lethal gynecological malignancy worldwide although exponential
progress has been made in its treatment over the last decade. New agents and novel …

The phosphoinositide-3-kinase (PI3K)/AKT pathway regulates cell survival and is over-
activated in most human cancers, including ovarian cancer. Following growth factor …

Combination chemotherapy appears to be a preferable option for some cancer patients,
especially when the medications target multiple pathways of oncogenesis; individuals …

Abstract Development of ovarian cancer involves the co-evolution of neoplastic cells
together with the adjacent microenvironment. Steps of malignant progression including …