The ability to design efficient enzymes from scratch would have a profound effect on
chemistry, biotechnology and medicine. Rapid progress in protein engineering over the past …

Since the first revelation of proteins functioning as macromolecular machines through their
three dimensional structures, researchers have been intrigued by the marvelous ways the …

Antibodies are immune system proteins that protect the host by binding to specific antigens
such as viruses and bacteria. The binding between antibodies and antigens is mainly …

Construction of a scaffold structure that supports a desired motif, conferring protein function,
shows promise for the design of vaccines and enzymes. But a general solution to this motif …

There has been considerable recent progress in protein structure prediction using deep
neural networks to predict inter-residue distances from amino acid sequences,–. Here we …

The recent devastating pandemic has drastically reminded humanity of the importance of
constant scientific and technological progress. A strong interdisciplinary dialogue between …

Antibodies are versatile proteins that bind to pathogens like viruses and stimulate the
adaptive immune system. The specificity of antibody binding is determined by …

Highlights⿢The recent use of deep learning has dramatically improved the accuracy of non-
homologous protein structure modeling.⿢Protein structure prediction problem was largely …

Computational antibody design seeks to automatically create an antibody that binds to an
antigen. The binding affinity is governed by the 3D binding interface where antibody …

Abstract Information in proteins flows from sequence to structure to function, with each step
causally driven by the preceding one. Protein design is founded on inverting this process …