Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways

MO Welcome, NE Mastorakis - Pharmacological research, 2020 - Elsevier
Stress is a nonspecific response to a threat or noxious stimuli with resultant damaging
consequences. Stress is believed to be an underlying process that can trigger central …

Secreted protease ADAMTS18 in development and disease

J Nie, W Zhang - Gene, 2023 - Elsevier
ADAMTS18 was identified in 2002 as a member of the ADAMTS family of 19 secreted Zinc-
dependent metalloproteinases. Prior to 2016, ADAMTS18 was known as a candidate gene …

Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation

S Neyazi, E Yamazawa, K Hack, S Tanaka… - Acta …, 2024 - Springer
Ependymomas encompass multiple clinically relevant tumor types based on localization and
molecular profiles. Tumors of the methylation class “spinal ependymoma”(SP-EPN) …

The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

D Ataca, P Aouad, C Constantin, C Laszlo… - Nature …, 2020 - nature.com
Estrogens and progesterone control breast development and carcinogenesis via their
cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How …

[HTML][HTML] Neural plasticity and depression treatment

YB Wang, NN Song, YQ Ding, L Zhang - IBRO Neuroscience Reports, 2023 - Elsevier
Depression is one of the most common mental disorders, which can lead to a variety of
emotional problems and even suicide at its worst. As this neuropsychiatric disorder causes …

ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis

J Nie, S Dang, R Zhu, T Lu, W Zhang - Breast Cancer Research, 2024 - Springer
Background Human epidermal growth factor receptor 2 (HER2)-positive breast cancer
accounts for about 20% of all breast cancer cases and is correlated with a high relapse rate …

Increased Anxiety-like Behaviors in Adgra1−/− Male But Not Female Mice are Attributable to Elevated Neuron Dendrite Density, Upregulated PSD95 Expression, and …

XH Zhang, CL Shen, XY Wang, WF Xiong, X Shang… - Neuroscience, 2022 - Elsevier
Adhesion G protein-coupled receptor A1 (ADGRA1) belongs to the G protein-coupled
receptor (GPCR) family, and its physiological function remains largely unknown. We found …

[HTML][HTML] ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells

L Wang, L He, W Yi, M Wang, F Xu, H Liu, J Nie… - Iscience, 2024 - cell.com
Liver sinusoidal endothelial cells (LSECs) have a unique morphological structure known as"
fenestra" that plays a crucial role in liver substance exchange and homeostasis …

[HTML][HTML] Ozone causes depressive-like response through PI3K/Akt/GSK3β pathway modulating synaptic plasticity in young rats

Q Cao, L Zou, Z Fan, Y Yan, C Qi, B Wu… - … and Environmental Safety, 2022 - Elsevier
Ozone pollution has been associated with several adverse effects, including memory
impairment, intellectual retardation, emotional disturbances. However, the potential …

ADAMTS18 deficiency leads to pulmonary hypoplasia and bronchial microfibril accumulation

T Lu, X Lin, YH Pan, N Yang, S Ye, Q Zhang, C Wang… - Iscience, 2020 - cell.com
ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) are secreted
metalloproteinases that play a major role in the assembly and degradation of the …