The last 40 years have witnessed how p53 rose from a viral binding protein to a central
factor in both stress responses and tumor suppression. The exquisite regulation of p53 …

Post-translational modifications of p53 are critical in modulating its tumor suppressive
functions. Ubiquitylation, for example, plays a major role in dictating p53 stability, subcellular …

The tumor suppressor protein p53 mediates stress-induced growth arrest or apoptosis and
plays a major role in safeguarding genome integrity. In response to DNA damage, p53 can …

Post-translationally modified proteins make up the majority of the proteome and establish, to
a large part, the impressive level of functional diversity in higher, multi-cellular organisms …

SOCS1 is lost in many human tumors, but its tumor suppression activities are not well
understood. We report that SOCS1 is required for transcriptional activity, DNA binding, and …

Human keratinocytes respond to UV rays by developing a fast adaptive response that
contributes to maintaining their functions and survival. We investigated the role of the …

The p53 protein is a pleiotropic regulator working as a tumor suppressor and as an
oncogene. Depending on the cellular insult and the mutational status, p53 may trigger …

Approximately 27 million people are suffering from cancer that contains either an
inactivating missense mutation of TP53 gene or partially abrogated p53 signaling pathway …

Alzheimer's disease is characterized by two protein precipitates, extracellular amyloid
plaques and intracellular neurofibrillary tangles (NFTs). The primary constituent of NFTs is a …

Although it is well-established that p53-mediated tumor suppression mainly acts through its
ability in transcriptional regulation, the molecular mechanisms of this regulation are not …