New pathological and clinical insights in endometrial cancer in view of the updated ESGO/ESTRO/ESP guidelines

A Santoro, G Angelico, A Travaglino, F Inzani… - Cancers, 2021 - mdpi.com
Simple Summary Histopathological classification of endometrial carcinoma has evidenced
two main groups with different biological behavior: low-grade (G1–G2) and high-grade (G3) …

Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis

J Huvila, J Pors, EF Thompson… - The Journal of …, 2021 - Wiley Online Library
Endometrial carcinoma (EC) is classified into a wide range of morphological variants; this list
has expanded over the past decade with the inclusion of mesonephric‐like and …

[HTML][HTML] Reproducibility of histological cell type in high-grade endometrial carcinoma

G Han, D Sidhu, MA Duggan, J Arseneau, M Cesari… - Modern pathology, 2013 - Elsevier
Subclassification of endometrial carcinoma according to histological type shows variable
interobserver agreement. The aim of this study was to assess specifically the interobserver …

The association and significance of p53 in gynecologic cancers: the potential of targeted therapy

M Nakamura, T Obata, T Daikoku… - International Journal of …, 2019 - mdpi.com
Dysfunction of p53 is observed in the many malignant tumors. In cervical cancer, p53 is
inactivated by degradation through the complex with human papilloma virus (HPV) …

The fallopian tube,“precursor escape” and narrowing the knowledge gap to the origins of high-grade serous carcinoma

TR Soong, BE Howitt, N Horowitz, MR Nucci… - Gynecologic …, 2019 - Elsevier
Most ovarian carcinomas are high-grade serous carcinomas (HGSC) that contain TP53
mutations, present at advanced stage, and eventually become resistant to chemotherapy …

Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer

T Bosse, NT Ter Haar, LM Seeber, FJ Hes… - Modern …, 2013 - nature.com
The switch/sucrose non-fermentable (SWI/SNF) subunit ARID1A (AT-rich interactive domain
1A gene) has been recently postulated as a novel tumor suppressor of gynecologic cancer …

Carcinogenic mechanisms of endometrial cancer: involvement of genetics and epigenetics

K Banno, M Yanokura, M Iida… - Journal of Obstetrics …, 2014 - Wiley Online Library
Endometrial cancer is increasing worldwide and the number of patients with this disease is
likely to continue to grow, including younger patients. Many endometrial cancers show …

The genomics and genetics of endometrial cancer

AJ O'Hara, DW Bell - Advances in genomics and genetics, 2012 - Taylor & Francis
Most sporadic endometrial cancers (ECs) can be histologically classified as endometrioid,
serous, or clear cell. Each histotype has a distinct natural history, clinical behavior, and …

Evidence for lineage continuity between early serous proliferations (ESPs) in the Fallopian tube and disseminated high‐grade serous carcinomas

TR Soong, BE Howitt, A Miron… - The Journal of …, 2018 - Wiley Online Library
The distal Fallopian tube is a site of origin for many 'ovarian'high‐grade serous carcinomas
(HGSCs) with intraepithelial carcinomas (STICs) that share identical TP53 mutations with …

New perspectives on screening and early detection of endometrial cancer

L Costas, J Frias‐Gomez, M Guardiola… - … journal of cancer, 2019 - Wiley Online Library
Due to the anatomical continuity of the uterine cavity with the cervix, genomic exploitation of
material from routine Pap smears and other noninvasive sampling methods represent a …