Pathobiology of the klotho antiaging protein and therapeutic considerations

GJ Prud'homme, M Kurt, Q Wang - Frontiers in Aging, 2022 - frontiersin.org
The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

Klotho's impact on diabetic nephropathy and its emerging connection to diabetic retinopathy

A Tang, Y Zhang, L Wu, Y Lin, L Lv, L Zhao… - Frontiers in …, 2023 - frontiersin.org
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide and
is a significant burden on healthcare systems. α-klotho (klotho) is a protein known for its anti …

Cardiac cachexia: unaddressed aspect in cancer patients

S Saha, PK Singh, P Roy, SS Kakar - Cells, 2022 - mdpi.com
Tumor-derived cachectic factors such as proinflammatory cytokines and neuromodulators
not only affect skeletal muscle but also affect other organs, including the heart, in the form of …

Microalgal nutraceuticals: unravelling solution to food-health nexus

D Garg, S Bala, UG Phutela - Phytochemistry Reviews, 2024 - Springer
Since the industrial revolution, the consumption of processed foods has skyrocketed
incredibly. Many of the inherent characteristics of food are lost during that process. Thus, an …

Clemastine mitigates sepsis-induced acute kidney injury in rats; the role of α-Klotho/TLR-4/MYD-88/NF-κB/Caspase-3/p-P38 MAPK signaling pathways

M Abdelnaser, ME Attya, MA El-Rehany… - Archives of Biochemistry …, 2025 - Elsevier
Sepsis is a fatal condition, with an annual incidence of more than 48 million cases as well as
11 million deaths resulting from it. Moreover, sepsis continues to rank as the fifth most …

Astaxanthin ameliorated isoproterenol induced myocardial infarction via improving the mitochondrial function and antioxidant activity in rats

DSE Mahmoud, MA Kamel… - … of Biochemical and …, 2024 - Wiley Online Library
The present study evaluated the cardioprotective effect of astaxanthin (ASX) against
isoproterenol (ISO) induced myocardial infarction in rats via the pathway of mitochondrial …

Mechanism Exploration of Astaxanthin in the Treatment of Adriamycin-induced Cardiotoxicity Based on Network Pharmacology and Experimental Validation

Y Zhu, M Chen, L Xie, Y Pan, Y Yang… - Current Medicinal …, 2024 - benthamdirect.com
Introduction Astaxanthin (AXT), a natural antioxidant recognized for its therapeutic potential
in cancer and cardiovascular diseases, holds promise in mitigating adriamycin-induced …

Astaxanthin protects against pirarubicin-induced H9c2 cardiomyocytes by adjusting microRNA-494-3p-mediated MDM4/p53 signalling pathway

P Huang, Y Zhang, F Wang, M Qin, J Ma… - Journal of Pharmacy …, 2023 - academic.oup.com
Purpose Pirarubicin (THP) is an antitumour drug widely used in clinical practice, but its
cardiotoxicity limits its application. THP cardiotoxicity must be treated as soon as possible …

Geraniol alleviates cyclophosphamide-induced cardiotoxicity in mice

S Karim, RA Shaik - Asian Pacific Journal of Tropical Biomedicine, 2024 - journals.lww.com
Objective: To explore the effect of geraniol on cyclophosphamide-induced cardiotoxicity.
Methods: Mice were divided into five groups: the control group, the cyclophosphamide group …

[HTML][HTML] Белок Klotho, фактор роста фибробластов 23 и склеростин при хронической сердечной недостаточности: обзор литературы

АМ Алиева, ЕВ Резник, ИА Котикова… - …, 2024 - cyberleninka.ru
Хроническая сердечная недостаточность (ХСН) является глобальной медицинской,
социальной и экономической проблемой. ХСН—это синдром, обусловленный …