Immunology of multiple sclerosis

M Sospedra, R Martin - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract Multiple sclerosis (MS) develops in young adults with a complex predisposing
genetic trait and probably requires an inciting environmental insult such as a viral infection …

The genetics of multiple sclerosis: an up‐to‐date review

PA Gourraud, HF Harbo, SL Hauser… - Immunological …, 2012 - Wiley Online Library
Multiple sclerosis (MS) is a prevalent inflammatory disease of the central nervous system
that often leads to disability in young adults. Treatment options are limited and often only …

New insights into apoptosis signaling by Apo2L/TRAIL

F Gonzalvez, A Ashkenazi - Oncogene, 2010 - nature.com
Apoptosis ligand 2 tumor necrosis factor (TNF)-related apoptosis-inducing ligand
(Apo2L/TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF …

Defining the response to interferon‐β in relapsing‐remitting multiple sclerosis patients

J Río, C Nos, M Tintoré, N Téllez, I Galán… - Annals of Neurology …, 2006 - Wiley Online Library
Objective Many patients with multiple sclerosis (MS) are currently receiving treatment with
interferon (IFN)–β. Early identification of nonresponder patients is crucial to try different …

Development of biomarkers in multiple sclerosis

B Bielekova, R Martin - Brain, 2004 - academic.oup.com
Multiple sclerosis is a complex disease, as several pathophysiological processes (including
inflammation, demyelination, axonal damage and repair mechanisms) participate in the …

The immune system on the TRAIL of Alzheimer's disease

C Burgaletto, A Munafò, G Di Benedetto… - Journal of …, 2020 - Springer
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive degeneration and loss of neurons in specific regions of the central nervous …

Defining interferon β response status in multiple sclerosis patients

RA Rudick, JC Lee, J Simon… - Annals of Neurology …, 2004 - Wiley Online Library
IFN‐β is effective in reducing relapses and magnetic resonance imaging (MRI) lesions in
multiple sclerosis (MS). It is assumed that individual therapeutic responses vary, but …

Activated human NK and CD8+ T cells express both TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated …

P Mirandola, C Ponti, G Gobbi, I Sponzilli… - Blood, 2004 - ashpublications.org
The expression of tumor necrosis factor (TNF)–related apoptosis-inducing ligand (TRAIL)
and TRAIL receptors was investigated in resting and cytokine-activated purified primary …

The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway

S Wang - Oncogene, 2008 - nature.com
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the
TNF superfamily and has been shown to induce apoptosis in cancer cells but not normal …

IL-17A mediates inflammatory and tissue remodelling events in early human tendinopathy

NL Millar, M Akbar, AL Campbell, JH Reilly, SC Kerr… - Scientific reports, 2016 - nature.com
Increasingly, inflammatory mediators are considered crucial to the onset and perpetuation of
tendinopathy. We sought evidence of interleukin 17A (IL-17A) expression in early human …