Background: Despite the implementation of the national control program, tuberculosis is one
of the greatest health problems in Iran. The prevalence of different strains in specific ethnic …

The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available
antibiotics, and requires new approaches to antibiotic discovery and development …

Tuberculosis is an ever-changing field. The editors and authors of “Tuberculosis 2007–from
basic science to patient care” have made every effort to provide information that is accurate …

Tuberculosis (TB) is a significant public health challenge, especially in developing nations.
Developing a TB eradication strategy is hampered by the global health concern of drug …

Chaperones aid in protein folding and maintenance of protein integrity. In doing so, they
have the unique ability to directly stabilize resistance-conferring amino acid substitutions in …

Background rpoB gene mutations in Mycobacterium tuberculosis (MTB) make the bacteria
resistant to rifampicin. Thus, these mutations are surrogate markers for multi-drug resistance …

Tuberculosis (TB) remains a significant global health problem for which rapid diagnosis is
critical to both treatment and control. This report describes a multiplex PCR method, the …

Background There is a growing need to develop rapid laboratory research methods to
counter the menace of drug resistant tuberculosis (MDR‐TB) cases worldwide especially in …

We determined the prevalence of rifampin-monoresistant tuberculosis (RMR-TB) in Iran.
Because development of RMR-TB is not common, we also identified the major risk factors …

OBJECTIVE: Isoniazid (INH) and rifampin (RIF) are the most effective first line antibiotics
against Mycobacterium tuberculosis. Mutations in several genes determine resistance of M …