Parvalbumin role in epilepsy and psychiatric comorbidities: from mechanism to intervention
Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …
essential role in regulating many physiological processes, such as intracellular signaling …
Contactin‐associated protein‐like 2, a protein of the neurexin family involved in several human diseases
M Saint‐Martin, B Joubert… - European Journal of …, 2018 - Wiley Online Library
Abstract Contactin‐associated protein‐like 2 (CASPR2) is a cell adhesion protein of the
neurexin family. Proteins of this family have been shown to play a role in the development of …
neurexin family. Proteins of this family have been shown to play a role in the development of …
Reduced prefrontal synaptic connectivity and disturbed oscillatory population dynamics in the CNTNAP2 model of autism
Loss-of-function mutations in CNTNAP2 cause a syndromic form of autism spectrum
disorder in humans and produce social deficits, repetitive behaviors, and seizures in mice …
disorder in humans and produce social deficits, repetitive behaviors, and seizures in mice …
Cerebellum-specific deletion of the GABAA receptor δ subunit leads to sex-specific disruption of behavior
Granule cells (GCs) of the cerebellar input layer express high-affinity δ GABA A subunit-
containing GABA A receptors (δGABA A Rs) that respond to ambient GABA levels and …
containing GABA A receptors (δGABA A Rs) that respond to ambient GABA levels and …
Disrupted AMPA receptor function upon genetic-or antibody-mediated loss of autism-associated CASPR2
D Fernandes, SD Santos, E Coutinho, JL Whitt… - Cerebral …, 2019 - academic.oup.com
Neuropsychiatric disorders share susceptibility genes, suggesting a common origin. One
such gene is CNTNAP2 encoding contactin-associated protein 2 (CASPR2), which harbours …
such gene is CNTNAP2 encoding contactin-associated protein 2 (CASPR2), which harbours …
CNTNAP2 stabilizes interneuron dendritic arbors through CASK
Contactin associated protein-like 2 (CNTNAP2) has emerged as a prominent susceptibility
gene implicated in multiple complex neurodevelopmental disorders, including autism …
gene implicated in multiple complex neurodevelopmental disorders, including autism …
GABAB Receptor Agonist R-Baclofen Reverses Altered Auditory Reactivity and Filtering in the Cntnap2 Knock-Out Rat
D Möhrle, W Wang, SN Whitehead… - Frontiers in Integrative …, 2021 - frontiersin.org
Altered sensory information processing, and auditory processing, in particular, is a common
impairment in individuals with autism spectrum disorder (ASD). One prominent hypothesis …
impairment in individuals with autism spectrum disorder (ASD). One prominent hypothesis …
Weaker neural suppression in autism
MP Schallmo, T Kolodny, AM Kale, R Millin… - Nature …, 2020 - nature.com
Abnormal sensory processing has been observed in autism, including superior visual
motion discrimination, but the neural basis for these sensory changes remains unknown …
motion discrimination, but the neural basis for these sensory changes remains unknown …
[HTML][HTML] Differences in startle and prepulse inhibition in contactin-associated protein-like 2 knock-out rats are associated with sex-specific alterations in brainstem …
The contactin-associated protein-like 2 (CNTNAP2) gene encodes for the CASPR2 protein,
which plays an essential role in neurodevelopment. Mutations in CNTNAP2 are associated …
which plays an essential role in neurodevelopment. Mutations in CNTNAP2 are associated …
Hyperexcitable and immature-like neuronal activity in the auditory cortex of adult rats lacking the language-linked CNTNAP2 gene
The contactin-associated protein-like 2 gene, CNTNAP2, is a highly penetrant risk gene
thought to play a role in the genetic etiology of language-related disorders, such as autism …
thought to play a role in the genetic etiology of language-related disorders, such as autism …