CRISPR‐Cas biochemistry and CRISPR‐based molecular diagnostics

Z Weng, Z You, J Yang, N Mohammad… - Angewandte Chemie …, 2023 - Wiley Online Library
Polymerase chain reaction (PCR)‐based nucleic acid testing has played a critical role in
disease diagnostics, pathogen surveillance, and many more. However, this method requires …

Recent applications of rolling circle amplification in biosensors and DNA nanotechnology

J Liu, G Xie, S Lv, Q Xiong, H Xu - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Isothermal nucleic acid amplification techniques have emerged as an important diagnostic
tool for clinical applications and food safety inspection. Rolling circle amplification (RCA) is …

MicroRNAome genome: a treasure for cancer diagnosis and therapy

I Berindan‐Neagoe, PC Monroig… - CA: a cancer journal …, 2014 - Wiley Online Library
The interplay between abnormalities in genes coding for proteins and noncoding
microRNAs (miRNAs) has been among the most exciting yet unexpected discoveries in …

Recent advances in signal amplification strategy based on oligonucleotide and nanomaterials for microRNA detection-a review

YX Chen, KJ Huang, KX Niu - Biosensors and Bioelectronics, 2018 - Elsevier
MicroRNAs (MiRNAs) play multiple crucial regulating roles in cell which can regulate one
third of protein-coding genes. MiRNAs participate in the developmental and physiological …

Systematic transcriptome wide analysis of lncRNA-miRNA interactions

S Jalali, D Bhartiya, MK Lalwani, S Sivasubbu… - PloS one, 2013 - journals.plos.org
Background Long noncoding RNAs (lncRNAs) are a recently discovered class of non-
protein coding RNAs, which have now increasingly been shown to be involved in a wide …

Rapid and multiplexed microRNA diagnostic assay using quantum dot-based forster resonance energy transfer

X Qiu, N Hildebrandt - ACS nano, 2015 - ACS Publications
The detection of next generation microRNA (miRNA) biomarkers has become a highly
important aspect for clinical diagnostics. We use multiplexed Förster resonance energy …

The fusion of two worlds: Non-coding RNAs and extracellular vesicles-diagnostic and therapeutic implications

Y Sato-Kuwabara, SA Melo… - … journal of oncology, 2015 - spandidos-publications.com
The role of the extracellular non-coding RNAs, particularly microRNAs present in tumor-
derived extravesicles, has been intensively exploited in human cancer as a promising tool …

In situ detection of plasma exosomal microRNA-1246 for breast cancer diagnostics by a Au nanoflare probe

LY Zhai, MX Li, WL Pan, Y Chen, MM Li… - … applied materials & …, 2018 - ACS Publications
Breast cancer is the second cause of cancer mortality in women globally. Early detection,
treatment, and metastasis monitoring are of great importance to favorable prognosis …

MicroRNAs in liver disease

XW Wang, NHH Heegaard, H Ørum - Gastroenterology, 2012 - Elsevier
MicroRNAs are small noncoding RNA molecules that regulate gene expression
posttranscriptionally through complementary base pairing with thousands of messenger …

MicroRNAs as biomarkers for CNS disease

P Rao, E Benito, A Fischer - Frontiers in molecular neuroscience, 2013 - frontiersin.org
For many neurological diseases, the efficacy and outcome of treatment depend on early
detection. Diagnosis is currently based on the detection of symptoms and neuroimaging …