Th17 cells produce IL-17, and the latter promotes bone loss in collagen-induced arthritis in
mice. Blocking IL-17 action in mouse model of rheumatoid arthritis reduces disease …

Background Small animal models are critical to model the complex disease mechanisms
affecting a functional joint leading to articular cartilage disorders. They are advantageous for …

Osteoporosis is a chronic systemic bone disease of growing relevance due to the on-going
demographic change. Since the underlying regulatory mechanisms of this critical illness are …

Background The human knee is a complex joint, and affected by a variety of articular
cartilage disorders. Large animal models are critical to model the complex disease …

Osteoporosis is a chronic systemic disease characterised by bone loss and
microarchitectural deterioration. Since the underlying regulatory mechanisms are still not …

Sheep ovariectomy (OVX) alone or associated to steroid therapy, deficient diet, or
hypothalamic–pituitary disconnection has proven to be of critical importance for …

Hypothalamo‐pituitary disconnection (HPD) leads to low bone turnover and osteoporosis in
sheep. To determine the sustainability of bone loss and its biomechanical relevance, we …

Osteoporosis is a bone disease resulting in increased fracture risk as a result of alterations
in both quantity and quality of bone. Bone quality is a combination of metabolic and …

The exact relationship between osteoporosis and osteoarthritis is still a matter for debate for
many. The ovariectomised ewe is frequently used as a model for osteoporosis, resulting in …

Osteopenia and subchondral microfractures are implicated in the aetiology of spontaneous
osteonecrosis of the knee (SPONK). The ovine tibia shows significant alterations of the …