Summary von Willebrand disease (VWD) is a bleeding disorder caused by inherited defects
in the concentration, structure, or function of von Willebrand factor (VWF). VWD is classified …

The physiological protection against bleeding is secured by platelet adhesion to the site of
injury and sealing of the defect. The first step involves the arrest of platelets that have …

von Willebrand disease (VWD) is a commonly encountered inherited bleeding disorder
affecting both males and females, causing mucous membrane and skin bleeding symptoms …

Von Willebrand factor (VWF) is secreted as ultralarge multimers that are cleaved in the A2
domain by the metalloprotease ADAMTS13 to give smaller multimers. Cleaved VWF is …

A plasma metalloprotease, ADAMTS13, cleaves von Willebrand factor (VWF) multimers and
downregulates their activity in platelet aggregation. Functional ADAMTS13 deficiency leads …

The common autosomally inherited mucocutaneous bleeding disorder, von Willebrand
disease (VWD) results from quantitative or qualitative defects in plasma von Willebrand …

The lengths of von Willebrand factor (VWF) concatamers correlate with hemostatic potency.
After secretion in plasma, length is regulated by hydrodynamic shear force-dependent …

Abstract von Willebrand factor (VWF) is amongst others synthesized by endothelial cells and
stored as ultra-large (UL) VWF multimers in Weibel-Palade bodies. Although UL-VWF is …

Everyone experiences minor bleeding and clotting, and many illnesses feature extremes of
hemorrhage or thrombosis. Recent advances have illuminated the ways in which von …

Endothelial cells secrete prothrombotic ultralarge von Willebrand factor (VWF) multimers,
and the metalloprotease ADAMTS13 cleaves them into smaller, less dangerous multimers …