Engineering strategies to safely drive CAR T-cells into the future
M Rossi, E Breman - Frontiers in Immunology, 2024 - frontiersin.org
Chimeric antigen receptor (CAR) T-cell therapy has proven a breakthrough in cancer
treatment in the last decade, giving unprecedented results against hematological …
treatment in the last decade, giving unprecedented results against hematological …
Advancements and challenges in developing in vivo CAR T cell therapies for cancer treatment
Summary The Chimeric Antigen Receptor (CAR) T cell therapy has emerged as a ground-
breaking immunotherapeutic approach in cancer treatment. To overcome the complexity and …
breaking immunotherapeutic approach in cancer treatment. To overcome the complexity and …
Steering the course of CAR T cell therapy with lipid nanoparticles
Lipid nanoparticles (LNPs) have proven themselves as transformative actors in chimeric
antigen receptor (CAR) T cell therapy, surpassing traditional methods and addressing …
antigen receptor (CAR) T cell therapy, surpassing traditional methods and addressing …
An overview of nanoparticle-based delivery platforms for mRNA vaccines for treating cancer
Y Lin, X Chen, K Wang, L Liang, H Zhang - Vaccines, 2024 - mdpi.com
With its unique properties and potential applications, nanoparticle-based delivery platforms
for messenger RNA (mRNA) vaccines have gained significant attention in recent years …
for messenger RNA (mRNA) vaccines have gained significant attention in recent years …
Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality
N von Auw, R Serfling, R Kitte, N Hilger, C Zhang… - Scientific Reports, 2023 - nature.com
Process development for transferring lab-scale research workflows to automated
manufacturing procedures is critical for chimeric antigen receptor (CAR)-T cell therapies …
manufacturing procedures is critical for chimeric antigen receptor (CAR)-T cell therapies …
Immunological nanomaterials to combat cancer metastasis
Metastasis causes greater than 90% of cancer-associated deaths, presenting huge
challenges for detection and efficient treatment of cancer due to its high heterogeneity and …
challenges for detection and efficient treatment of cancer due to its high heterogeneity and …
Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity
L Wu, X Li, X Qian, S Wang, J Liu, J Yan - Vaccines, 2024 - mdpi.com
In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor
immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great …
immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great …
mRNA‐Engineered CD5‐CAR‐γδTCD5‐ Cells for the Immunotherapy of T‐Cell Acute Lymphoblastic Leukemia
Z Zhu, H Li, Q Lu, Z Zhang, J Li, Z Wang… - Advanced …, 2024 - Wiley Online Library
Abstract Clinical trials of Chimeric Antigen Receptor T‐cell (CAR‐T) therapy have
demonstrated remarkable success in treating both solid tumors and hematological …
demonstrated remarkable success in treating both solid tumors and hematological …
Recent advances and applications of the CRISPR-Cas system in the gene therapy of blood disorders
Clinical gene therapy has faced numerous challenges and obstacles in the last few years.
However, it has made significant advances in treatment and is now in clinical trials and on …
However, it has made significant advances in treatment and is now in clinical trials and on …
Advances in manufacturing chimeric antigen receptor immune cell therapies
A Ramamurthy, A Tommasi, K Saha - Seminars in Immunopathology, 2024 - Springer
Biomedical research has witnessed significant strides in manufacturing chimeric antigen
receptor T cell (CAR-T) therapies, marking a transformative era in cellular immunotherapy …
receptor T cell (CAR-T) therapies, marking a transformative era in cellular immunotherapy …