Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

There are many instances in life when the environment plays a critical role in the health
outcomes of an individual, yet none more so than those experienced in fetal and neonatal …

Due to the high prevalence of diabetes worldwide, extensive research is still being
performed to develop new antidiabetic agents and determine their mechanisms of action …

A growing body of evidence suggests that the intrauterine (IU) environment has a significant
and lasting effect on the long-term health of the growing fetus and the development of …

Fetal intrauterine growth restriction has been associated with adult disease in both human
epidemiologic studies and in animal models. In some cases, intrauterine deprivation …

Fetal growth retardation is a fetal adaptation in response to inadequate supply of oxygen
and/or nutrients. Animal models of intrauterine growth retardation are an invaluable tool to …

The intrauterine growth restricted (IUGR) fetus develops unique metabolic adaptations in
response to exposure to reduced nutrient supply. These adaptations provide survival value …

Intrauterine growth restriction (IUGR) leads to reduced birth weight and the development of
metabolic diseases such as Type 2 diabetes in adulthood. Mitochondria dysfunction and …

The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are two
closely related and liver-enriched nuclear hormone receptors originally defined as …

Diabetes is one of the major global public health problems and is gradually getting worse
particularly in developing nations where 95% of patients are suffering from type 2 diabetes …