When stiffness matters: mechanosensing in heart development and disease
During embryonic morphogenesis, the heart undergoes a complex series of cellular
phenotypic maturations (eg, transition of myocytes from proliferative to quiescent or …
phenotypic maturations (eg, transition of myocytes from proliferative to quiescent or …
Recent computational approaches on mechanical behavior of axonal cytoskeletal components of neuron: A Brief Review
Axonal cytoskeletal components of neuron have been studied and modeled by using
different approaches. The axonal cytoskeleton comprises of microtubules (MTs), which …
different approaches. The axonal cytoskeleton comprises of microtubules (MTs), which …
Charge-dependent interactions of monomeric and filamentous actin with lipid bilayers
CFE Schroer, L Baldauf, L van Buren… - Proceedings of the …, 2020 - National Acad Sciences
The cytoskeletal protein actin polymerizes into filaments that are essential for the
mechanical stability of mammalian cells. In vitro experiments showed that direct interactions …
mechanical stability of mammalian cells. In vitro experiments showed that direct interactions …
A mechanochemical model of actin filaments
In eukaryotic cells, actin filaments are involved in important processes such as motility,
division, cell shape regulation, contractility, and mechanosensation. Actin filaments are …
division, cell shape regulation, contractility, and mechanosensation. Actin filaments are …
Multiscale impact of nucleotides and cations on the conformational equilibrium, elasticity and rheology of actin filaments and crosslinked networks
Cells are able to respond to mechanical forces and deformations. The actin cytoskeleton, a
highly dynamic scaffolding structure, plays an important role in cell mechano-sensing. Thus …
highly dynamic scaffolding structure, plays an important role in cell mechano-sensing. Thus …
Cell penetrating peptide adsorption on magnetite and silica surfaces: a computational investigation
Magnetic nanoparticles (MNPs) represent one of the most promising materials as they can
act as a versatile platform in the field of bionanotechnology for enhanced imaging …
act as a versatile platform in the field of bionanotechnology for enhanced imaging …
The role of structural polymorphism in driving the mechanical performance of the alzheimer's beta amyloid fibrils
Alzheimer's Disease (AD) is related with the abnormal aggregation of amyloid β-peptides
Aβ1− 40 and Aβ1− 42, the latter having a polymorphic character which gives rise to U-or S …
Aβ1− 40 and Aβ1− 42, the latter having a polymorphic character which gives rise to U-or S …
A coarse-grained multiscale model to simulate morphological changes of food-plant tissues undergoing drying
Numerical modelling has emerged as a powerful and effective tool to study various dynamic
behaviours of biological matter. Such numerical modelling tools have contributed to the …
behaviours of biological matter. Such numerical modelling tools have contributed to the …
Insights into actin polymerization and nucleation using a coarse-grained model
BG Horan, AR Hall, D Vavylonis - Biophysical Journal, 2020 - cell.com
We studied actin filament polymerization and nucleation with molecular dynamics
simulations and a previously established coarse-grained model having each residue …
simulations and a previously established coarse-grained model having each residue …
Coarse-Grain Model of Ultrarigid Polymer Rods Comprising Bifunctionally Linked Peptide Bundlemers
Computationally designed homotetrameric helical peptide bundles have been
functionalized at their N-termini to achieve supramolecular polymers, wherein individual …
functionalized at their N-termini to achieve supramolecular polymers, wherein individual …