Purpose Age‐related macular degeneration (AMD) is a degenerative disease of the macula,
often leading to progressive vision loss. The rate of disease progression can vary among …

Age-related macular degeneration (AMD) is a complex multifactorial disease and the
primary cause of legal and irreversible blindness among individuals aged≥ 65 years in …

Purpose: To study the levels of complement activation in different disease stages of AMD
and the influence of genetic polymorphisms in complement genes. Methods: We included …

Biomarkers can help unravel mechanisms of disease and identify new targets for therapy.
They can also be useful in clinical practice for monitoring disease progression, evaluation of …

This work reviews concepts regarding oxidative stress and the mechanisms by which
endogenous and exogenous factors produce reactive oxygen species (ROS). It also surveys …

Zinc is an essential nutrient for human health. It plays key roles in maintaining protein
structure and stability, serves as catalytic factor for many enzymes, and regulates diverse …

Nowadays, aging is understood as a dynamic and multifaceted dysregulation process that
spares almost no human organ or cell. The immune system being among the most affected …

Zinc is an element of great biological significance. Many biochemical processes cannot
occur without zinc as it is required for large number of physiological functions. It plays an …

Purpose To identify genetic variants associated with complement activation, which may help
to select age-related macular degeneration (AMD) patients for complement-inhibiting …

Ophthalmologists are long familiar with the eye showing signs of systemic disease, but the
association between age-related macular degeneration and abnormal complement …