Correlates of protection (CoPs) are increasingly important in the development and licensure
of vaccines. Although the study of CoPs was initially directed at identifying a single immune …

The extent to which immune responses to natural infection with severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against …

There is a vital need for authentic COVID-19 animal models to enable the pre-clinical
evaluation of candidate vaccines and therapeutics. Here we report a dose titration study of …

Influenza is a major global public health threat as a result of its highly pathogenic variants,
large zoonotic reservoir, and pandemic potential. Metagenomic viral sequencing offers the …

Current flu vaccines rely on the induction of strain-specific neutralizing antibodies, which
leaves the population vulnerable to drifted seasonal or newly emerged pandemic strains …

An ideal vaccine both attenuates virus growth and disease in infected individuals and
reduces the spread of infections in the population, thereby generating herd immunity …

Universal influenza vaccines should protect against continuously evolving and newly
emerging influenza viruses. T cells may be an essential target of such vaccines, as they can …

Both natural infection with SARS-CoV-2 and immunization with a number of vaccines induce
protective immunity. However, the ability of such immune responses to recognize and …

Measles cases have surged pre-COVID-19 and the pandemic has aggravated the problem.
Most measles-associated morbidity and mortality arises from destruction of pre-existing …

In December 2019 an outbreak of coronavirus disease (COVID-19) emerged in Wuhan,
China. The causative agent was subsequently identified and named severe acute …