Increasing evidence points to biological sex as an important factor in the development and
phenotypical expression of Parkinson's disease (PD). Risk of developing PD is twice as high …

Parkinson's disease is a progressive neurodegenerative disease characterized by the loss
of dopaminergic neurons of the nigrostriatal pathway and the formation of neuronal …

In recent years, multiple lines of evidence from human genetic and molecular studies have
highlighted the importance of the autophagy lysosomal pathway (ALP) in Parkinson's …

The accumulation and misfolding of α‐synuclein (α‐syn) represent the main pathological
hallmark of PD. Overexpression of α‐syn and failure of cellular protein degradation systems …

LRRK2 has been implicated in endolysosomal function and likely plays a central role in
idiopathic Parkinson's disease (iPD). In iPD, dopaminergic neurons within the substantia …

Abstract Background Haploinsufficiency in the Gaucher disease GBA gene, which encodes
the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for …

Parkinson's disease (PD) is a progressive disorder that belongs to a class of
neurodegenerative disorders (NDs) called Synucleinopathies. It has characterized by the …

Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) are symptomatically
characterized by parkinsonism, with the latter presenting additionally a distinctive range of …

Background Mutations in the GBA gene, which encodes the lysosomal enzyme
glucocerebrosidase (GCase), are risk factors for Parkinson's disease (PD). Objective To …

Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, and its prevalence is increasing with age. A wealth of genetic evidence …