Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …

Cancer stem cells (CSCs) are a great challenge in the fight against cancer because these
self-renewing tumorigenic cell fractions are thought to be responsible for metastasis …

Heat shock factor 1 (HSF1) was discovered in 1984 as the master regulator of the heat
shock response. In this classical role, HSF1 is activated following cellular stresses such as …

The heat-shock, or HSF1-mediated proteotoxic stress, response (HSR/HPSR) is
characterized by induction of heat-shock proteins (HSPs). As molecular chaperones, HSPs …

The ability of cancer cells to cope with stressful conditions is critical for their survival,
proliferation, and metastasis. The heat shock transcription factor 1 (HSF1) protects cells from …

Chronic inflammation has been closely linked to the development and progression of
various cancers. The epithelial–mesenchymal transition (EMT) is a process involving the …

Cancer is one of the leading causes of death globally according to the World Health
Organization. Although improved treatments and early diagnoses have reduced cancer …

Abstract Heat shock factor 1 (HSF1) systematically guards proteome stability and
proteostasis by regulating the expression of heat shock protein (HSP), thus rendering cancer …

Ovarian cancer is a serious cause of death in gynecological oncology. Delayed diagnosis
and poor survival rates associated with late stages of the disease are major obstacles …