This review summarizes the current knowledge on the physiological action of endogenous
and exogenous pulmonary surfactant, the role of different types of animal-derived and …

Pulmonary surfactant is a complex of lipids and proteins assembled and secreted by the
alveolar epithelium into the thin layer of fluid coating the respiratory surface of lungs. There …

Objective To evaluate the possible noninferiority of surfactant administration via laryngeal
mask airway (LMA) vs endotracheal tube (ETT) in avoiding the requirement for mechanical …

Delivery of medications to preterm neonates receiving non-invasive ventilation (NIV)
represents one of the most challenging scenarios for aerosol medicine. This challenge is …

Yearly more than 15 million babies are born premature (< 37 weeks gestational age),
accounting for more than 1 in 10 births worldwide. Lung injury caused by maternal …

RESULTS Nine studies recruiting 1095 infants met inclusion criteria. SN compared with
standard care significantly reduced intubation rate at 72 hours after birth (226 of 565 infants …

Bronchopulmonary dysplasia (BPD) is a complex disorder with multiple factors implicated in
its etiopathogenesis. Despite the scientific advances in the field of neonatology, the …

In the last 4 decades, advances in neonatology have led to a significant increase in the
survival of preterm infants. One of the biggest advances was the introduction of surfactant …

Purpose Improving the deep lung delivery of aerosol surfactant therapy (AST) with a dry
powder formulation may enable significant reductions in dose while providing improved …

Background Non-invasive delivery of nebulized surfactant has been a neonatology long-
pursued goal. Nevertheless, the clinical efficacy of nebulized surfactant remains …