Ankylosing spondylitis: etiology, pathogenesis, and treatments

W Zhu, X He, K Cheng, L Zhang, D Chen, X Wang… - Bone research, 2019 - nature.com
Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …

Psoriatic arthritis from a mechanistic perspective

G Schett, P Rahman, C Ritchlin, IB McInnes… - Nature Reviews …, 2022 - nature.com
Psoriatic arthritis (PsA) is part of a group of closely related clinical phenotypes ('psoriatic
disease') that is defined by shared molecular pathogenesis resulting in excessive …

The pathogenesis of psoriatic arthritis

DJ Veale, U Fearon - The Lancet, 2018 - thelancet.com
Psoriatic arthritis is a chronic, immune-mediated, inflammatory arthropathy that presents with
inflammation of the joints and entheses, including those of the axial skeleton, and is …

Enthesitis: from pathophysiology to treatment

G Schett, RJ Lories, MA D'Agostino… - Nature reviews …, 2017 - nature.com
Entheses are the insertion sites of tendons and ligaments to the bone surface and are
essential structures for locomotion. Inflammation of the entheses (enthesitis) is a key feature …

Use of IL-23 inhibitors for the treatment of plaque psoriasis and psoriatic arthritis: a comprehensive review

K Yang, ASW Oak, BE Elewski - American journal of clinical dermatology, 2021 - Springer
Psoriasis is a common inflammatory skin disease with multiple comorbidities, including
psoriatic arthritis and coronary artery disease, that can severely impact an individual's …

Pineal calcification, melatonin production, aging, associated health consequences and rejuvenation of the pineal gland

DX Tan, B Xu, X Zhou, RJ Reiter - Molecules, 2018 - mdpi.com
The pineal gland is a unique organ that synthesizes melatonin as the signaling molecule of
natural photoperiodic environment and as a potent neuronal protective antioxidant. An intact …

Effects of the IL-23–IL-17 pathway on bone in spondyloarthritis

EM Gravallese, G Schett - Nature Reviews Rheumatology, 2018 - nature.com
Over the past several years, a pathophysiological role for the IL-23–IL-17 pathway in human
disease has been defined. A subset of rheumatic diseases, including psoriatic arthritis (PsA) …

Biomimetic Hydroxyapatite Nanorods Promote Bone Regeneration via Accelerating Osteogenesis of BMSCs through T Cell-Derived IL-22

F Yu, R Lian, L Liu, T Liu, C Bi, K Hong, S Zhang… - Acs Nano, 2022 - ACS Publications
Manipulations of morphological properties of nanobiomaterials have been demonstrated to
modulate the outcome of osteoimmunomodulation and eventually osteogenesis through …

Cartilage and bone destruction in arthritis: pathogenesis and treatment strategy: a literature review

D Tateiwa, H Yoshikawa, T Kaito - Cells, 2019 - mdpi.com
Arthritis is inflammation of the joints accompanied by osteochondral destruction. It can take
many forms, including osteoarthritis, rheumatoid arthritis, and psoriatic arthritis. These …

[HTML][HTML] Recent advances in ankylosing spondylitis: understanding the disease and management

L Garcia-Montoya, H Gul, P Emery - F1000Research, 2018 - ncbi.nlm.nih.gov
The term spondyloarthritis refers to a group of immune-mediated diseases characterised by
inflammation of the axial skeleton, peripheral joints, and entheses. Ankylosing spondylitis …