Microcarriers for upscaling cultured meat production

V Bodiou, P Moutsatsou, MJ Post - Frontiers in nutrition, 2020 - frontiersin.org
Due to the considerable environmental impact and the controversial animal welfare
associated with industrial meat production, combined with the ever-increasing global …

Large-scale production of stem cells utilizing microcarriers: a biomaterials engineering perspective from academic research to commercialized products

H Tavassoli, SN Alhosseini, A Tay, PPY Chan, SKW Oh… - Biomaterials, 2018 - Elsevier
Human stem cells, including pluripotent, embryonic and mesenchymal, stem cells play
pivotal roles in cell-based therapies. Over the past decades, various methods for expansion …

[HTML][HTML] Application of human mesenchymal and pluripotent stem cell microcarrier cultures in cellular therapy: achievements and future direction

AKL Chen, S Reuveny, SKW Oh - Biotechnology advances, 2013 - Elsevier
Mesenchymal stem cells (MSCs) have recently made significant progress with multiple
clinical trials targeting modulation of immune responses, regeneration of bone, cartilage …

Designing microgels for cell culture and controlled assembly of tissue microenvironments

AS Caldwell, BA Aguado… - Advanced functional …, 2020 - Wiley Online Library
Micrometer‐sized hydrogels, termed microgels, are emerging as multifunctional platforms
that can recapitulate tissue heterogeneity in engineered cell microenvironments. The …

Production and utility of extracellular vesicles with 3D culture methods

M Casajuana Ester, RM Day - Pharmaceutics, 2023 - mdpi.com
In recent years, extracellular vesicles (EVs) have emerged as promising biomarkers, cell-
free therapeutic agents, and drug delivery carriers. Despite their great clinical potential, poor …

Chitosan-collagen hydrogel microparticles as edible cell microcarriers for cultured meat

A Zernov, L Baruch, M Machluf - Food Hydrocolloids, 2022 - Elsevier
Offering conventional meat-like nutritional values and eating experience without harming
animals or the environment, cultured meat from livestock animal cells is considered one of …

Microfluidics-assisted fabrication of gelatin-silica core–shell microgels for injectable tissue constructs

C Cha, J Oh, K Kim, Y Qiu, M Joh, SR Shin… - …, 2014 - ACS Publications
Microfabrication technology provides a highly versatile platform for engineering hydrogels
used in biomedical applications with high-resolution control and injectability. Herein, we …

Microparticles in contact with cells: from carriers to multifunctional tissue modulators

MD Neto, MB Oliveira, JF Mano - Trends in biotechnology, 2019 - cell.com
For several decades microparticles have been exclusively and extensively explored as
spherical drug delivery vehicles and large-scale cell expansion carriers. More recently …

Scaffold geometry modulation of mechanotransduction and its influence on epigenetics

P Han, GA Gomez, GN Duda, S Ivanovski, PSP Poh - Acta biomaterialia, 2023 - Elsevier
The dynamics of cell mechanics and epigenetic signatures direct cell behaviour and fate,
thus influencing regenerative outcomes. In recent years, the utilisation of 2D geometric (ie …

Engineered protein coatings to improve the osseointegration of dental and orthopaedic implants

J Raphel, J Karlsson, S Galli, A Wennerberg, C Lindsay… - Biomaterials, 2016 - Elsevier
Here we present the design of an engineered, elastin-like protein (ELP) that is chemically
modified to enable stable coatings on the surfaces of titanium-based dental and orthopaedic …