Cerebral cavernous malformations (CCM) are vascular malformations that can occur as a
sporadic or a familial autosomal dominant disorder. Clinical and cerebral MRI data on large …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID), autism and
schizophrenia, have high socioeconomic impact, yet poorly understood etiologies. A recent …

The serine/threonine protein phosphatases are targeted to specific subcellular locations and
substrates in part via interactions with a wide variety of regulatory proteins. Understanding …

Background—Cerebral cavernous malformation (CCM) is a hemorrhagic stroke disease
affecting up to 0.5% of North Americans that has no approved nonsurgical treatment. A …

Objective To compare clinical features of CCM1, CCM2, and CCM3 mutation carriers.
Methods A detailed clinical and molecular analysis of 163 consecutive cerebral cavernous …

Cerebral cavernous malformations (CCM) are vascular lesions which can occur as a
sporadic (80% of the cases) or familial autosomal dominant form (20%). Three CCM genes …

Cerebral cavernous malformations (CCMs) are human vascular malformations caused by
mutations in three genes of unknown function: CCM1, CCM2, and CCM3. CCM3, also …

Cerebral cavernous malformations (CCMs) are alterations in brain capillary architecture that
can result in neurological deficits, seizures, or stroke. We recently demonstrated that CCM3 …

Cerebral cavernous malformation is a common human vascular disease that arises due to
loss-of-function mutations in genes encoding three intracellular adaptor proteins, cerebral …

PDCD10 (programmed cell death 10, TFAR15), a novel protein associated with cell
apoptosis has been recently implicated in mutations associated with Cerebral Cavernous …