The tumour suppressor p53 is the most frequently mutated gene in human cancer, with more
than half of all human tumours carrying mutations in this particular gene. Intense efforts to …

While the tumor suppressor functions of p53 have long been recognized, the contribution of
p53 to numerous other aspects of disease and normal life is only now being appreciated …

The DNA damage response (DDR) generates transient repair compartments to concentrate
repair proteins and activate signaling factors. The physicochemical properties of these …

Inhibition of the BRAF (V600E) oncoprotein by the small-molecule drug PLX4032
(vemurafenib) is highly effective in the treatment of melanoma. However, colon cancer …

The traditional view of p53 activation includes three steps—p53 stabilization, DNA binding,
and transcriptional activation. However, recent studies indicate that each step of p53 …

The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …

Currently, around 11 million people are living with a tumour that contains an inactivating
mutation of TP53 (the human gene that encodes p53) and another 11 million have tumours …

A large-scale RNA interference screen to discover genes involved in trastuzumab resistance
in breast cancer identified only PTEN as a modulator of drug sensitivity. Oncogenic mutants …

Inhibitors of the ALK and EGF receptor tyrosine kinases provoke dramatic but short-lived
responses in lung cancers harboring EML4-ALK translocations or activating mutations of …

Mutations in TP53, the gene that encodes the tumour suppressor p53, are found in 50% of
human cancers, and increased levels of its negative regulators MDM2 and MDM4 (also …