The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes
develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin …

Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a conserved
protein kinase that plays essential roles in various biological processes. It is located in the …

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

According to the World Health Organization (WHO), 422 million people are suffering from
diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose …

Abstract Type 2 diabetes (T2D) is associated with β-cell dedifferentiation. Aldehyde
dehydrogenase 1 isoform A3 (ALHD1A3) is a marker of β-cell dedifferentiation and …

Background Single-cell RNA sequencing (scRNA-seq) provides valuable insights into
human islet cell types and their corresponding stable gene expression profiles. However …

Resistance to regeneration of insulin-producing pancreatic β cells is a fundamental
challenge for type 1 and type 2 diabetes. Recently, small molecule inhibitors of the kinase …

Prevention or amelioration of declining β cell mass is a potential strategy to cure diabetes.
Here, we report the pathways utilized by β cells to robustly replicate in response to acute …

Background Stem cell therapies are finally coming of age as a viable alternative to
pancreatic islet transplantation for the treatment of insulin-dependent diabetes. Several …