Light‐based technique, including optical imaging and photoregulation, has become one of
the most important tools for both fundamental research and clinical practice, such as cell …

Bioluminescence has long been used to image biological processes in vivo. This technology
features luciferase enzymes and luciferin small molecules that produce visible light …

With the ability to noninvasively image and monitor molecular processes within tumors,
molecular imaging represents a fundamental tool for cancer scientists. In the current review …

The widely used coelenterazine-powered Renilla luciferase was discovered over 40 years
ago, but the oxidative mechanism by which it generates blue photons remains unclear. Here …

Molecular imaging is a biomedical research discipline that has quickly emerged to afford the
observation, characterization, monitoring, and quantification of biomarkers and biological …

Nicotinamide riboside (NR) is a form of vitamin B 3 and is one of the most studied
compounds for the restoration of cellular NAD+ levels demonstrating clinical potential in …

Iron is an essential metal for all organisms, yet disruption of its homeostasis, particularly in
labile forms that can contribute to oxidative stress, is connected to diseases ranging from …

The bioluminescence signal generated by the luciferase-luciferin interaction, exploited for
real-time and continuous monitoring of numerous biochemical processes in living cells and …

The first reporter systems were developed in the early 1980s and were based on measuring
the activity of an enzyme—as a surrogate measure of promoter-driven transcriptional activity …

Ovarian cancer is the most lethal gynecological cancer type in the United States. The
success of current chemotherapies is limited by chemoresistance and side effects. Targeted …