Organic compounds labeled with hydrogen isotopes play a crucial role in numerous areas,
from materials science to medicinal chemistry. Indeed, while the replacement of hydrogen by …

C–H deuteration has been intricately developed to satisfy the urgent need for site-selectively
deuterated organic frameworks. Deuteration has been primarily used to study kinetic isotope …

This review provides a synthetic overview of the recent research advancements addressing
the topic of catalysis with colloidal ruthenium metal nanoparticles through the last five years …

In this review the applications of isotopically labeled compounds are discussed and put into
the context of their future impact in the life sciences. Especially discussing their use in the …

For the first time, we describe highly selective homogeneous iridium‐catalyzed hydrogen
isotope exchange (HIE) of unactivated C (sp3) centers in aliphatic amides. When using the …

Conspectus Recently, hydrogen isotope exchange (HIE) reactions have experienced
impressive development due to the growing importance of isotope containing compounds in …

A two-step degradation–reconstruction approach to the carbon-14 radiolabeling of alkyl
carboxylic acids is presented. Simple activation via redox-active ester formation was …

The preparation of N‐heterocyclic carbene‐stabilized iridium nanoparticles and their
application in hydrogen isotope exchange reactions is reported. These air‐stable and easy …

The introduction of deuterium and tritium into molecules is of great importance in drug
discovery. Many attempts have been made to develop late-stage hydrogen isotope …

This review summarizes the highlights of aliphatic C (sp3)‐H carbon hydrogen isotope
exchange (HIE) methods developed in the last 10 years. In particular, new highly selective …