Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis

MM Poon, KI Lorrain, KJ Stebbins, GC Edu… - Proceedings of the …, 2024 - pnas.org
Multiple sclerosis (MS) is a chronic and debilitating neurological disease that results in
inflammatory demyelination. While endogenous remyelination helps to recover function, this …

[HTML][HTML] Protective effect of 3-n-butylphthalide against intrastriatal injection of malonic acid-induced neurotoxicity and biochemical alteration in rats

C Yuan, L Zheng, Y Zhao - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Mitochondrial abnormalities and a defective expression of neurotrophic factors contribute to
neuronal damage in Huntington's disease (HD). HD patients showed a reduction in …

Abdominal surgery plus sevoflurane exposure induces abnormal emotional changes and cognitive dysfunction in aged rats

JM Lv, LM Zhang, JX Wang, JJ Shao, XG Guo… - Behavioural Brain …, 2023 - Elsevier
Background Cognitive impairment, which includes perioperative psychological distress and
cognitive dysfunction, can be determined by preoperative and post-operative …

Oligodendrocyte progenitor cells' fate after neonatal asphyxia—Puzzling implications for the development of hypoxic–ischemic encephalopathy

J Janowska, J Gargas, K Zajdel, M Wieteska… - Brain …, 2024 - Wiley Online Library
Premature birth or complications during labor can cause temporary disruption of cerebral
blood flow, often followed by long‐term disturbances in brain development called hypoxic …

Sobetirome rescues α‐synuclein‐mediated demyelination in an in vitro model of multiple system atrophy

L Mészáros, M Himmler, Y Schneider… - European Journal of …, 2024 - Wiley Online Library
Multiple system atrophy (MSA) is a rare and rapidly progressive atypical parkinsonian
disorder characterized by oligodendroglial cytoplasmic inclusions containing α‐synuclein (α …

[图书][B] Structural and functional characterization of multiple system atrophy and promyelinogenic repair strategies

L Mészáros - 2022 - search.proquest.com
Classified as atypical parkinsonian disorder, multiple system atrophy (MSA) is an orphan,
but rapidly progressive neurodegenerative disease without curative therapy at present. With …

Perinatal fluoxetine exposure and myelination: are the MBP and MAG protein levels altered?

M Visser - 2023 - fse.studenttheses.ub.rug.nl
SSRI treatment during the perinatal period is considered to be safe for the offspring as it has
no gross neuroteratogenic effects on them. Yet, previous research showed that perinatal …