The progress we have made in understanding Alzheimer's disease (AD) pathogenesis has
led to the identification of several novel pathways and potential therapeutic targets. Rho …

Silent information regulator sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase with potent
anti-arterial aging activities. Its protective function in aging-related diseases has been …

Postsynaptic proteins play crucial roles in synaptic function and plasticity. During brain
development, alterations in synaptic number, shape, and stability occur, known as synapse …

Classical Rho GTPases, including RhoA, Rac1, and Cdc42, are members of the Ras small
GTPase superfamily and play essential roles in a variety of cellular functions. Rho GTPase …

Background Alzheimer's disease (AD) is a progressive, chronic, and neurodegenerative
disease, and the most common cause of dementia worldwide. Currently, the mechanisms …

One of the earliest pathological features characterizing Alzheimer's disease (AD) is the loss
of dendritic spines. Among the many factors potentially mediating this loss of neuronal …

Chronic exposure to high circulating levels of glucocorticoids (GCs) may be a key risk factor
for Alzheimer's Disease (AD) development and progression. In addition, hyper-activation of …

Alzheimer's Disease (AD) and Type 2 Diabetes (T2D) share a common hallmark of insulin
resistance. Reportedly, two non-canonical Receptor Tyrosine Kinases (RTKs), ALK and …

The intracellular tyrosine kinase Pyk2 (PTK2B) is related to focal adhesion kinase and
localizes to postsynaptic sites in brain. Pyk2 genetic variation contributes to late onset …

The Small GTPase Rac1 is critical for various fundamental cellular processes, including
cognitive functions. The cyclical activation and inactivation of Rac1, mediated by Rac …