Background Over the past 20 years, insights from human and mouse genetics have
illuminated the central role of the brain leptin-melanocortin pathway in the control of …

The lateral hypothalamic area (LHA) is a subcortical brain region that exerts control over
motivated behavior, feeding, and energy balance across species. Recent single-cell …

Abstract The melanocortin‐4 receptor (MC4R) has been critically investigated for the past
two decades, and novel findings regarding MC4R signalling and its potential exploitation in …

The ventromedial hypothalamus (VMH) is a critical neural node that senses blood glucose
and promotes glucose utilization or mobilization during hypoglycemia. The VMH neurons …

Growth hormone secretagogue receptor 1a (GHSR1a), a member of the G protein-coupled
receptor (GPCR) family, is a functional receptor of ghrelin. The expression levels and …

Variants in the gene encoding ankyrin repeat and SOCS box–containing 4 (ASB4) are
linked to human obesity. Here, we characterized the pathways underlying the metabolic …

Obesity/overweight are important health problems due to metabolic complications.
Dysregulation of peptides exerting orexigenic/anorexigenic effects must be investigated in …

Physical inactivity is a major public health problem that contributes to the development of
several pathologies such as obesity, type 2 diabetes and cardiovascular diseases. Regular …

The central melanocortin system is fundamentally important for controlling food intake and
energy homeostasis. Melanocortin‐3 receptor (MC3R) is one of two major receptors of the …

As the most recent melanocortin receptor (MCR) identified, melanocortin-5 receptor (MC5R)
has unique tissue expression patterns, pharmacological properties, and physiological …