Emerging roles of angiopoietin‐like proteins in inflammation: Mechanisms and potential as pharmacological targets

J Yang, Q Song, S Niu, H Chen… - Journal of cellular …, 2022 - Wiley Online Library
Abstract Angiopoietin‐like proteins (ANGPTLs), a family of eight secreted glycoproteins
termed ANGTPL1‐8, are involved in angiogenesis, lipid metabolism, cancer progression …

Progress of antibody–drug conjugates (ADCs) targeting c-Met in cancer therapy; insights from clinical and preclinical studies

AH Mer, Y Mirzaei, F Misamogooe, N Bagheri… - Drug Delivery and …, 2024 - Springer
The cell-surface receptor tyrosine kinase c-mesenchymal-epithelial transition factor (c-Met)
is overexpressed in a wide range of solid tumors, making it an appropriate target antigen for …

ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE−/− mice

H Yu, X Jiao, Y Yang, Q Lv, Z Du, L Li, C Hu… - Clinical …, 2023 - portlandpress.com
Abstract Angiopoietin-like protein 8 (ANGPTL8) plays important roles in lipid metabolism,
glucose metabolism, inflammation, and cell proliferation and migration. Clinical studies have …

Emerging insights into the roles of ANGPTL8 beyond glucose and lipid metabolism

H Ye, Q Zong, H Zou, R Zhang - Frontiers in Physiology, 2023 - frontiersin.org
Angiopoietin-like protein 8 (ANGPTL8) is a secreted protein predominantly expressed in
liver and adipose tissue. ANGPTL8 modulates the clearance of triglycerides (TGs) by …

Contribution of organokines in the development of NAFLD/NASH associated hepatocellular carcinoma

M Vachher, S Bansal, B Kumar, S Yadav… - Journal of Cellular …, 2022 - Wiley Online Library
Globally the incidence of hepatocellular carcinoma (HCC) is on an upsurge. Evidence is
accumulating that liver disorders like nonalcoholic fatty liver disease (NAFLD) and its more …

ANGPTL8 roles in proliferation, metabolic diseases, hypothyroidism, polycystic ovary syndrome, and signaling pathways

M Navaeian, S Asadian, H Ahmadpour Yazdi… - Molecular biology …, 2021 - Springer
A new and atypical member of the ANGPTL family is angiopoietin-like protein 8 (ANGPTL8).
This newly discovered hormone is a drug target that can be used to treat diabetes and …

[PDF][PDF] Serum betatrophin and irisin levels in hepatocellular carcinoma.

M Pazgan-Simon, J Zuwala-Jagiello… - Journal of Physiology …, 2020 - jpp.krakow.pl
Hepatocellular carcinoma (HCC) development is a complex process with well-known risk
factors, however the role of betatrophin/angiopoietin-like protein 8 and irisin has been poorly …

The role of ANGPTL gene family members in hepatocellular carcinoma

Y Bai, D Lu, D Qu, Y Li, N Zhao, G Cui, X Li… - Disease …, 2022 - Wiley Online Library
Background. Hepatocellular carcinoma (HCC) is highly aggressive with a poor prognosis
and survival rate. Certain ANGPTL members have been implicated in tumor progression …

A new cytotoxic sesquiterpene lactone from Euphorbia microsphaera Boiss against human breast cancer (MCF-7) and human fibrosarcoma (HT1080) cells

K Azizi, A Hamedi, N Azarpira, A Hamedi, M Shahini… - Toxicon, 2021 - Elsevier
A new guaianolide sesquiterpene lactone with cytotoxic properties was isolated from
Euphorbia microsphaera Boiss. To determine the highest active fraction and isolate …

Chimeric antigen receptor-natural killer cells: a promising sword against insidious tumor cells

T Hojjatipour, Z Sharifzadeh, A Maali, M Azad - Human Cell, 2023 - Springer
Natural killer (NK) cells are a critical component of innate immunity, particularly in initial
cancer recognition and inhibition of additional tumor growth or metastasis propagation. NK …